Differential Regulation of the Cell Cycle by α1-Adrenergic Receptor Subtypes
نویسندگان
چکیده
منابع مشابه
Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypes.
Recent data suggest that beta-adrenergic receptor subtypes couple differentially to signaling pathways regulating cardiac function vs. cardiac remodeling. To dissect the roles of beta1- vs. beta2-receptors in the pathogenesis of cardiomyopathy, doxorubicin was administered to beta1, beta2, and beta1/beta2 knockout (-/-) and wild-type mice. Expression and activation of MAPKs were measured. Wild-...
متن کاملDifferential cardioprotective/cardiotoxic effects mediated by !-adrenergic receptor subtypes
Bernstein, Daniel, Giovanni Fajardo, Mingming Zhao, Takashi Urashima, Jennifer Powers, Gerald Berry, and Brian K. Kobilka. Differential cardioprotective/cardiotoxic effects mediated by !-adrenergic receptor subtypes. Am J Physiol Heart Circ Physiol 289: H2441–H2449, 2005. First published July 22, 2005; doi:10.1152/ajpheart.00005.2005.—Recent data suggest that !-adrenergic receptor subtypes coup...
متن کاملDifferential regulation of functional responses by β-adrenergic receptor subtypes in brown adipocytes.
Brown adipose tissue contains both β1- and β3-adrenergic receptors (β-ARs), and whereas both receptor subtypes can activate adenylyl cyclase, recent studies suggest that these subtypes have different pharmacological properties and may serve different signaling functions. In this study, primary brown adipocyte cultures were used to determine the role of β-AR subtypes in mediating lipolysis and u...
متن کاملSustained Hypoxic Pulmonary Vasoconstriction in the Isolated Perfused Rat Lung: Effect of α1-adrenergic Receptor Agonist
Background: Alveolar hypoxia induces monophasic pulmonary vasoconstriction in vivo, biphasic vasoconstriction in the isolated pulmonary artery, and controversial responses in the isolated perfused lung. Pulmonary vascular responses to sustained alveolar hypoxia have not been addressed in the isolated perfused rat lung. In this study, we investigated the effect of sustained hypoxic ventilation o...
متن کاملTwo alpha1-adrenergic receptor subtypes regulating the vasopressor response have differential roles in blood pressure regulation.
To study the functional role of individual alpha1-adrenergic (AR) subtypes in blood pressure (BP) regulation, we used mice lacking the alpha1B-AR and/or alpha1D-AR with the same genetic background and further studied their hemodynamic and vasoconstrictive responses. Both the alpha1D-AR knockout and alpha1B-/alpha1D-AR double knockout mice, but not the alpha1B-AR knockout mice, had significantly...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Endocrinology
سال: 2004
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2004-0728